Allie's question: What are some signs of depression in cats and dogs? I've heard stories about dogs being treated with antidepressants. What are your thoughts on animal psychiatry? What other options are available for sad pets?

Heather Oxford, DVM: Veterinarians have the most extensive training in animal behavior of anyone working in the pet industry, and I doubt any one of us has ever prescribed antidepressants as a first-line for animal depression.

The reason is simple: There is a language barrier between us and our patients that does not exist in human medicine. Animals don't come into our offices and tell us that their hearing or vision is failing them, that they've had a chronic headache for weeks now, or that they've been having stomach or intestinal pains that just won't go away. They just look sad. It is our first responsibility to rule out causes of depression that are endocrine/internal, neurologic or orthopedic in origin. A lot of medical causes of depression can be treated, avoiding the unnecessary use of prescription antidepressants.

For the small population of animals whose depression truly can be traced to behavioral origins, I like a natural anti-depressant called S-adenosyl methionine (SAMe). This is a naturally occurring compound found in every cell of the body, made from the amino acid methionine. Although SAMe has many uses, there is evidence for its short-term use in treating major depression by assisting the body in producing neurotransmitters such as dopamine and serotonin. For cats, Feliway diffusers are helpful as well. There are also floral essences and homeopathic remedies that are useful for depression disorders. For animals that need stronger antidepressants, there are prescription-strength drugs available at your veterinarian's office; however, I reserve these for last.