Before taking Lysodren (Lysodren (Mitotane)), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Before using Lysodren (Mitotane), tell your doctor or pharmacist your medical history, especially of: current infection (especially viral infections such as chickenpox, herpes), blood pressure problems, liver disease.
Lysodren (Mitotane) may make you dizzy or drowsy. Use caution while driving, using machinery, or doing any activity that requires alertness. Limit alcoholic beverages.
Lysodren (Mitotane) can make it difficult to control your blood pressure. To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
If you have been using this product, your body may not produce enough natural steroids. You may need to start taking additional corticosteroids (e.g., hydrocortisone), especially if your body is stressed due to a major infection, surgery or injury. Tell your doctor immediately if a stress situation (e.g., trauma, surgery, serious infection) is occurring or any of the following side effects occur: unusual weakness, sudden weight loss, dizziness. This advice applies during and up to 8 months after stopping Lysodren (Lysodren (Mitotane)) treatment. Carry an emergency card or bracelet with this information. Consult your doctor or pharmacist for more details.
During pregnancy, Lysodren (Mitotane) should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known if Lysodren (Mitotane) passes into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using Lysodren (Mitotane). Consult your doctor before breast-feeding.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Keep all medications away from children and pets
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
Take Lysodren (Mitotane) by mouth with or without food, usually 3 or 4 times daily or as directed by your doctor. Lysodren (Mitotane) is often started in the hospital, where your doctor can follow you closely as your dose is adjusted to the best dose for you. Dosage of Lysodren (Mitotane) is based on your medical condition and response to therapy (e.g., cortisol levels).
Usually, you will need to take replacement corticosteroids (e.g., hydrocortisone) every day while you are taking Lysodren (Mitotane) and for some time after stopping Lysodren (Lysodren (Mitotane)).
Use Lysodren (Mitotane) regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not increase your dose or take Lysodren (Mitotane) more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.
It may take up to several months to receive the full benefit from Lysodren (Mitotane). Inform your doctor if your condition persists or worsens.
Since Lysodren (Mitotane) can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle Lysodren (Mitotane) or breathe the dust from the tablets. Learn proper technique for safe handling and disposal of this medicine and its container. Consult your pharmacist.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
Dizziness, drowsiness, nausea, diarrhea, loss of appetite, headache, or unusual weakness may occur. If these effects persist or worsen, notify your doctor promptly.
Remember that your doctor has prescribed Lysodren (Mitotane) because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Lysodren (Mitotane) do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: severe dizziness, flushing, fast/pounding heartbeat, shakiness (tremors), unusual/rapid weight loss, change in skin color/thickness.
Tell your doctor immediately if any of these rare but very serious side effects occur: easy bleeding/bruising, breast tenderness/enlargement (males), unwanted facial/body hair (females), mental/mood changes (e.g., depression, irritability, difficulty concentrating, confusion), speech problems, numbness/tingling of hands/feet, unsteadiness, pink urine, vision problems.
Lysodren (Mitotane) can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.
Lysodren (Mitotane) can commonly cause a rash that usually goes away. However, you may not be able to tell it apart from a rash that could be a sign of a severe reaction. Therefore, seek immediate medical attention if you develop a rash.
A very serious allergic reaction to Lysodren (Mitotane) is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
If you miss a dose of Lysodren (Mitotane), take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using Lysodren (Mitotane), tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin), corticosteroids (e.g., dexamethasone, prednisone), "water pills"/diuretics (e.g., furosemide, spironolactone), drugs removed from your body by certain liver enzymes (such as barbiturates, phenytoin).
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).
Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.
This product can affect the results of certain lab tests (including thyroid function tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Lysodren (Mitotane).
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
IMPORTANT NOTE: This information is provided for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.